| Medication: | Generic Azithromycin | Generic Azithromycin |
| Dosage: | 1000 mg, 500 mg, 250 mg | 250 mg, 500 mg, 1000 mg |
| Generic Zithromax 500 mg Price: | from $1.39 per pill | from $1.50 per pill |
| Shipment: | Express (1-3 business days), Airmail – Free (5-7 days) | Airmail – Free (5-7 days) |
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Indications ZITHROMAX
They proceed from the antibacterial activity and the pharmacokinetic characteristics of azithromycin. They take into account both the clinical studies that have given rise to Azithromycin and its place in the range of antibacterial products currently available.
They are limited to infections due to germs defined as sensitive :
- *documented beta-hemolytic streptococcus A angina, as an alternative to beta-lactam therapy, especially when it cannot be used,
- *superinfections of acute bronchitis,
- *exacerbations of chronic bronchitis,
- *stomatological infections.
Official recommendations regarding the appropriate use of antibacterial drugs should be taken into account.
How to take ZITHROMAX
Dosage
Dosage
Adult
- * angina, stomatological infections: 500 mg (2 tablets) per day for 3 days.
This dosage, with a short duration of administration of 3 days, is explained by the particular pharmacokinetic properties of azithromycin and the maintenance of activity, in these indications, several days after the last intake.
- * superinfections of acute bronchitis, exacerbations of chronic bronchitis: 500 mg (2 tablets) on the first day then 250 mg (1 tablet) the following 4 days. The duration of treatment will be 5 days.
Elderly subject
The recommended dosage is the same as for the adult patient. Elderly patients may present with pro-arrhythmogenic conditions, caution is particularly recommended due to the risk of occurrence of cardiac arrhythmia and torsades de pointes (see section Warnings and precautions for use).
Hepatic insufficiency
The dosage is the same in patients with moderate to moderate hepatic impairment (see section Warnings and precautions for use).
Method of administration
The tablets can be taken with or without meals, in a single daily dose.
Hypersensitivity
As with erythromycin and other macrolides, rare severe allergic reactions such as angioedema and anaphylactic reactions (rarely fatal) have been reported. The possibility of recurrence of manifestations after discontinuation of symptomatic treatment requires prolongation of monitoring and possibly treatment.
Skin reactions
In addition, serious life-threatening skin reactions such as cases of Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS syndrome (drug hypersensitivity syndrome with eosinophilia and systemic symptoms) and acute generalized exanthematic pustulosis (PEAG) have been reported. Patients should be warned about monitoring skin effects as well as suggestive signs and symptoms that usually appear in the first weeks of treatment. In case of suggestive symptoms (e.g. progressive skin rash often associated with lesions or blisters on the mucous membranes), azithromycin should be stopped immediately. It is recommended not to reintroduce treatment.
Hepatotoxicity
Since the liver is the main route of elimination of azithromycin, the prescription of azithromycin is not recommended in patients with severe liver failure or in patients with severe cholestasis.
Cases of fulminant hepatitis that can lead to life-threatening liver failure have been reported with azithromycin (see section Adverse Reactions). Some patients may have had a pre-existing liver disease or have taken other hepatotoxic drugs.
Liver function examinations should be carried out immediately if signs or symptoms of impaired liver function occur, such as the rapid onset of asthenia associated with jaundice, dark urine, a tendency to bleeding or hepatic encephalopathy. Taking azithromycin should be discontinued immediately if liver dysfunction occurs.
Diarrhea associated with Clostridium difficile
Cases of Clostridium difficile-associated diarrhea (DACD) have been reported with the use of virtually all antibiotics, including azithromycin. Their severity can range from mild diarrhea to life-threatening pseudomembranous colitis. Treatment with antibiotics modifies the flora of the colon, thus leading to an excessive proliferation of C. difficile.
C. difficile produces toxins A and B, which contribute to the development of DACD. These toxin-producing strains increase morbidity and mortality, as infections may be refractory to antibiotic treatment and require a colectomy. The presence of DACD should be considered in all patients who develop diarrhea after the use of antibiotics. It is important that this diagnosis is mentioned in patients who present with diarrhea during or after taking an antibiotic since cases have been observed up to 2 months after stopping treatment.
Myasthenia Gravis
Exacerbations of myasthenia gravis symptoms and new outbreaks of myasthenic syndrome have been reported in patients taking azithromycin (see section Adverse Reactions).
Superinfection
As with all antibiotics, monitoring for signs of superinfection by non-sensitive organisms, including fungi, is recommended.
Derivatives of ergot of rye
In the case of treatment with ergot derivatives, certain macrolide antibiotics administered concomitantly precipitated ergotism. There are no data as to a possible interaction between ergot and azithromycin. However, given the theoretical risk of ergotism, ergot derivatives and azithromycin should not be administered together (see sections Contraindications and Interactions with other drugs and other forms of interactions).
Hypertrophic stenosis of the infant's pylorus
Cases of hypertrophic stenosis of the infant's pylorus have been reported with the use of azithromycin in newborns (treatment up to 42 days of life). Parents and caregivers should be informed to contact the doctor in case of vomiting or the occurrence of hyperreactivity to food.
Renal insufficiency
In the case of severe renal insufficiency (glomerular filtration rate < 10 ml/min), a 33% increase in systemic exposure to azithromycin was observed.
It is not useful to adjust the dosage in patients with mild renal impairment (creatinine clearance greater than 40 ml/min). In patients with a creatinine clearance of less than 40 ml/min, the prescription of azithromycin should be cautious.
Related to excipients
Azithromycin contains lactose. Patients with galactose intolerance, total lactase deficiency or glucose-galactose malabsorption syndrome (rare hereditary diseases) should not take Azithromycin.
Azithromycin contains less than 1 mmol (23 mg) of sodium per tablet, that is to say that it is essentially "sodium-free".
Pregnancy and lactation ZITHROMAX
Pregnancy
1st quarter :
It is preferable, as a precautionary measure, not to use azithromycin in the first trimester of pregnancy. Indeed, although the animal data on rodents do not show any malformative effect, the clinical data are insufficient.
From the second trimester :
Due to the expected benefit, the use of azithromycin can be considered from the second trimester of pregnancy if necessary. Indeed, although they are limited, the clinical data are reassuring in case of use beyond the first trimester.
Breastfeeding
Azithromycin is excreted in breast milk. A risk for newborns/infants cannot be ruled out. A decision must be made either to interrupt breastfeeding or to interrupt or abstain from treatment, taking into account the benefit of breastfeeding for the child compared to the benefit of treatment for the woman.
Side effects :
In about 10% of cases, gastrointestinal-type side effects. In the majority of cases (4%) diarrhea, but also nausea and vomiting, dyspepsia and stomach ache.
Allergic reactions, rarely dangerous, are possible.
Rare side effects :
Cardiovascular disorders, kidney and liver diseases, pseudomembranous colitis, pancreatitis, severe skin reactions and hearing disorders.
Azithromycin, like other macrolides, can prolong the QT interval and, rarely and especially in high-risk patients, can cause fatal cardiac arrhythmias.
Contraindications :
Hypersensitivity to azithromycin, patients with risk of prolongation of the QT interval.
Interactions :
Azithromycin is a substrate of cytochrome CYP3A4. Beware of drugs that can increase the time of the QT interval (e.g. amiodarone, methadone).
Other interactions: vitamin K antagonists, statins (muscle risks), digoxin (increased toxicity risk).
Pregnancy :
Azithromycin can be prescribed during pregnancy without any particular risk.
In what form (dosage forms)?
Azithromycin is commercially available in the form of film-coated tablets (250 to 500 mg), powder for the preparation of a suspension (600 to 1200 mg for a suspension of 40 mg/ml) and granules (100, 300 and 500 mg). In addition, granules for the production of an oral suspension with delayed release of the active ingredient are available. Since 2023, there has been an azithromycin-based ophthalmic preparation (Azyter®) in Switzerland for bacterial conjunctivitis.
Dosage and intake :
The drug is usually administered only once a day for 3 days, sometimes 1 day (this is called a single dose).
In general, 500 mg per 24 h for 3 days during respiratory tract infections. In general, 1000 mg (per 24 h) in a single dose for uncomplicated chlamydia.
It is possible to take azithromycin outside of meals.
Antibiotic against chlamydia: which one to take to treat yourself?
To treat your chlamydial infection quickly, whether you are a man or a woman, a doctor may prescribe antibiotics, either azithromycin or doxycycline. Azythromycin is a single-dose antibiotic (1 gram) used in the treatment of chlamydia. If your doctor prescribes doxycycline, you will need to take it for 7 days, twice a day.
Amoxicillin is not necessarily associated with these antibiotics against chlamydia. Whether in men or women, the treatment of chlamydial infection remains the same. Always consult a doctor to receive antibiotic treatment because you will need a prescription to get them.
What to do so that the antibiotic against chlamydia is effective?
To increase the chances of success of antibiotic treatment against chlamydia, follow these tips :
- follow your doctor's instructions about taking the antibiotic carefully ;
- tell your partner to get tested and treated as well ;
- wait for healing to have sex or only with condom ;
- if your symptoms persist or worsen, contact your doctor.
Good to know: the antibiotics to be taken if chlamydia has infected the throat and not the genitals are the same.
After how long is the treatment of chlamydia effective?
The duration of treatment for chlamydia depends on what the doctor prescribes for you. One-dose antibiotics (single sachet) used for chlamydia take a short time to take effect. The symptoms, if there are any, disappear quickly. To check that the treatment has worked well, we may suggest that you take a new screening test 1 month after the end of the treatment.
What to do if chlamydia returns after antibiotic treatment?
The success rate of chlamydia treatments is very high. However, it happens to develop resistance to antibiotics prescribed against chlamydia. In this case, the doctor will be able to adapt the prescription. If the first antibiotic was ineffective in treating chlamydia, he may give you another one. So do not hesitate to contact your doctor if your chlamydia symptoms return.
Side effects of antibiotics against chlamydia
Like any antibiotic treatment, those used to treat chlamydia trachomatis can occasionally cause side effects. The most common side effects are diarrhea, headache, fever, vomiting, nausea, abdominal pain and abnormalities in the blood formulation (NFS). However, side effects remain infrequent.
Can chlamydia heal on its own?
Unfortunately, it is better to consult quickly without waiting for a spontaneous cure for chlamydia, as this is not possible. Moreover, many people are carriers of the bacteria without knowing it because they have no symptoms. If you have had sexual intercourse with an infected person, you should get tested. Moreover, chlamydia is one of the STIs systematically searched for during screenings in sexually active people.
Can I get chlamydia treatment without a prescription?
It is not possible to treat chlamydia without antibiotics and this type of treatment is not sold without a prescription. You must therefore get tested and consult a doctor in order to obtain a medical prescription. Self-medication is not recommended, as you risk treating yourself incorrectly.
How to cure chlamydia naturally?
There are no natural treatments or remedies to cure chlamydia. If you test positive, you should definitely consult a doctor. You can also do it by teleconsultation, easily from your computer or phone. Doctors are at your disposal 7/7 and can issue you an online prescription, if necessary.
Which antibiotic to treat an STI?
Antibiotics do not cure all sexually transmitted infections. Antibiotic treatments, however, work for gonococcus (gonorrhea), but not for herpes, for example. Moreover, if you suffer from a double infection with gonococcus and chlamydia, you can be treated for both diseases at the same time, with dual antibiotic therapy.
How to do the chlamydia screening?
To be tested for chlamydia, you must perform a urine analysis test for men, or a vaginal self-swab sample in the laboratory. In both cases, you can consult a doctor on video and receive a prescription in order to be reimbursed. Free screening centers do not always do the test for chlamydia.
How to get a prescription for treatment quickly?
The easiest and fastest way is to call to receive a Zithromax prescription online. By making an appointment with a doctor on Qare, you can send documents to the doctor via the interface. This allows you to send the results of your screening test. If necessary, he will be able to prescribe a suitable treatment to treat you, and this without going to the office.
How do we know if we have chlamydia?
Only 30% of infected women and 50% of infected men show symptoms of chlamydia. This is why a test for this disease is almost systematically offered to people who wish to be screened for STIs. When it manifests itself, chlamydia can lead to very annoying symptoms.
In women, the symptoms are as follows :
- whitish vaginal discharge, a sign that there is a inflammation of the uterus ;
- pain and burning when urinating ;
- small bleeding outside menstruation or after intercourse ;
- pain during intercourse ;
- pain in the lower abdomen ;
- rectal pain ;
- discharge from the anus.
In mans, the symptoms may include :
- urethritis that causes pain when urinating ;
- pain in the testicles ;
- pain in the rectum.
How is chlamydia transmitted?
Chlamydia is a sexually transmitted infection. It is therefore transmitted during sexual intercourse of any kind. This can be during genital, anal, oral-genital intercourse, during foreplay and during contact with vaginal secretions or semen.
