| Drug Name: | Trazodone |
| Generic Name: | Trazonil |
| Tablet Strength: | 25 mg, 50 mg, 100 mg |
| Best Price Per Pill: | $0.45 |
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| Shipment: | Express (1-3 business days), Airmail – Free (5-7 days) |
| Prescription: | Over the Counter |
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- How does Trazodone work? What are its effects?
- In what forms does Trazodone come in?
- How should Trazodone be used?
- In what cases is Trazodone not recommended?
- What are the possible side effects of Trazodone?
- Are there any other precautions for use or warnings?
- Can other medicines interact with Trazodone?
How does Trazodone work? What are its effects?
Trazodone belongs to the class of drugs called antidepressants. It is used to treat the symptoms of depression. It works by modifying the balance, in the brain, of the chemical substances associated with depression. It may take 4 weeks before the benefits of this drug fully intervene.
Trazodone is available under various brand names or in different presentations. A specific brand of this drug may not be available in all forms or have been approved for all the conditions discussed here. In addition, some forms of this drug may not be used for all the conditions mentioned in this article.
It could be that your doctor has suggested Trazodone for a condition that is not listed in Trazodone information article. If you have not discussed this with your doctor yet, or if you have any doubts about why you are taking Trazodone, consult with him. Do not stop taking Trazodone without first consulting your doctor.
Do not give Trazodone to anyone, even to someone who suffers from the same symptoms as yours. Trazodone could harm people for whom it has not been prescribed.
In what forms does Trazodone come in?
50 mg
Each orange, round, biconvex tablet, bearing the inscription "Trazodone" on one side and "pms" and "50" on either side of the break bar on the other side, contains 50 mg of trazodone hydrochloride equivalent to 45.5 mg of trazodone base. Non-medicinal ingredients: corn starch, croscarmellose sodium, dicalcium phosphate, aluminum lacquer AD and C yellow nº 6, lactose, magnesium stearate, and microcrystalline cellulose.
75 mg
Each salmon, round, biconvex tablet, bearing the inscription "Trazodone" on one side and "pms" above "75" on the other, contains 75 mg of trazodone hydrochloride equivalent to 68.25 mg of trazodone base. Non-medicinal ingredients: aluminum lacquer AD and C yellow nº 6, corn starch, microcrystalline cellulose, croscarmellose sodium, lactose, dibasic calcium phosphate and magnesium stearate.
100 mg
Each white, round, biconvex tablet, bearing the inscription "Trazodone" on one side and "pms" and "100" on either side of the break bar on the other side, contains 100 mg of trazodone hydrochloride equivalent to 91 mg of trazodone base. Non-medicinal ingredients: corn starch, microcrystalline cellulose, croscarmellose sodium, lactose, dibasic calcium phosphate and magnesium stearate.
How should Trazodone be used?
The recommended dose of trazodone for an adult varies between 150 mg and 300 mg per day, divided into 2 or 3 doses, with a meal or a light snack.
The starting dose is usually 150 mg to 200 mg per day and then is gradually increased until the ideal dose is found.
Several factors can come into play when determining the dose a person needs: their weight, their state of health and the intake of other medications.
If your doctor has recommended a dose other than those indicated here, do not change the way you take the medicine without consulting him first.
It is very important that Trazodone is taken as directed by your doctor. If you miss a dose, take the medicine as soon as you notice the omission. If it is almost time for your next dose, do not worry about the missed dose and resume the usual dosing schedule. Do not use a double dose to make up for missing a dose. If you are unsure what to do after missing a dose, ask your doctor or a pharmacist for advice.
Store Trazodone at room temperature, away from light and moisture, and out of the reach of children.
Do not dispose of medicines in waste water (e.g. not in the sink or in the toilet bowl) or with household waste. Ask your pharmacist how to dispose of unused or expired medicines.
In what cases is Trazodone not recommended?
Do not take Trazodone if you are allergic to trazodone or any of its ingredients.
What are the possible side effects of Trazodone?
Many drugs can cause side effects. A side effect is an undesirable response to a drug when it is taken in normal doses. It can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by all people who take Trazodone. If you are worried about side effects, discuss the risks and benefits of Trazodone with your doctor.
At least 1% of people taking Trazodone have reported the following side effects. Many of these side effects can be managed and a few may go away on their own over time.
Consult your doctor if you experience these side effects and if they are serious or bothersome. Your pharmacist may be able to give you advice on what to do if these side effects appear :
- a constipation
- diarrhea
- a decrease in sexual abilities or desire
- dizziness or a light-headed feeling
- from weakness
- from fatigue
- headaches
- from nausea
- from nervousness
- a dry mouth
- from drowsiness
- vomiting
Most of the side effects listed below do not occur very often, but they could nevertheless cause serious problems if you do not consult your doctor or if you do not receive medical attention.
Check with your doctor as soon as possible if any of the following side effects occur :
- visual field abnormalities
- the appearance or aggravation of emotional disorders
- breast augmentation (for men)
- changes in the menstrual cycle
- from the confusion
- a discharge of milk (in the case of women, even in those who are not pregnant)
- dizziness when getting up after being in a sitting or lying position
- signs of bleeding disorders (e.g. unusual nosebleeds, bruises, blood in the urine, cough with bloody sputum, bleeding gums, cuts that do not stop bleeding)
- symptoms attributable to a low level of sodium in the blood (tiredness, weakness, mental confusion accompanied by soreness and muscle stiffness or difficulty coordinating the movements of the different muscles)
- symptoms of glaucoma (e.g. blurred vision, a halo of bright colors around light sources, red eyes, increased pressure in the eyes, pain or an unpleasant sensation in the eyes)
- symptoms of mania (e.g. an excited or irritable mood, a reduced need for sleep, thoughts that pass quickly)
- blurred vision.
Stop taking the medicine and seek medical attention immediately if there is a response like :
- convulsions
- a painful erection of the penis over a long period of time (lasting more than 4 hours)
- thoughts of suicide or self-harm
- signs attributable to bleeding from the stomach (e.g. bloody, black or tar-like stools, the presence of blood in the sputum, the presence of blood or a substance resembling coffee grounds in vomiting)
- symptoms of a serious allergic reaction (swelling of the face or throat, difficulty breathing, wheezing, or an itchy rash)
- symptoms of serotonin syndrome (e.g. confusion, rapid heartbeat, hallucinations, restlessness, tremors, shivering, sudden muscle jerk, sweating).
Some people may experience side effects other than those listed. Consult your doctor if you notice any symptom that worries you while you are using Trazodone.
Are there any other precautions for use or warnings?
Before using any medication, be sure to inform your doctor about any medical conditions or allergies you may have, the medications you are using and any other important facts about your health. Women should mention whether they are pregnant or breastfeeding. These factors could have an influence on how you should use Trazodone.
Alcohol and other medicines that may cause drowsiness: Do not combine Trazodone with alcohol or other medicines (e.g. antidepressants, sleeping pills, anxiolytics) that cause drowsiness because a dangerous addition effect of drowsiness may occur.
Discontinuation of the medication: If taking Trazodone must be suspended, the interruption should be done gradually, under the supervision of your doctor. Suddenly stopping taking trazodone can cause anxiety, restlessness and sleep problems.
Dizziness: trazodone can cause severe dizziness, especially when a person changes from sitting or lying down to standing. People who are taking medications that may cause dizziness should get up slowly from a sitting or lying position to reduce the possibility of experiencing significant dizziness or fainting.
Glaucoma: trazodone can worsen the symptoms of glaucoma (increased pressure in the eyes) such as blurred vision, pain in the eyes or eye pressure. If you have glaucoma, discuss with your doctor how Trazodone may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Trazodone, and whether any special monitoring is needed.
Behavioral changes and suicidal thoughts: Trazodone may worsen the symptoms of depression, including suicidal thoughts and the intention to harm yourself or someone. It can also lead to restlessness or aggressive behavior. If you notice such symptoms or any other behavioral changes while taking Trazodone, contact a doctor immediately. Family members or caregivers of people taking Trazodone should contact their doctor immediately if they notice any unusual behavioral changes.
Heart rhythm: trazodone can change the normal heart rhythm, including causing irregular beats called QT prolongation. This prolongation is a serious life-threatening disorder and can cause fainting, seizures and sudden death. If you are at risk of having a heart rhythm disorder (e.g. if you have heart failure or angina, or if your potassium or magnesium level is low), discuss with your doctor how Trazodone may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Trazodone, and whether any special monitoring is needed.
Blood pressure: trazodone can cause a drop in blood pressure and, perhaps, a light-headed feeling when getting up from a sitting or lying position.
Priapism: trazodone has been associated with prolonged or inappropriate erections (priapism) in the case of a number of men who have taken Trazodone.
If this side effect occurs, stop taking Trazodone immediately and contact your doctor.
Bleeding: trazodone can cause a drop in the number of platelets in the blood, which makes bleeding more difficult to stop. If you notice signs of bleeding, such as frequent nosebleeds, unexplained bruises, or blackish, tarry stools, report it to your doctor at the earliest. Your doctor will ask for regular blood tests to ensure that any potential problems are detected early.
Drowsiness or reduced alertness: trazodone can reduce the mental or physical abilities necessary for dangerous tasks such as driving a car or operating machinery. Avoid driving, operating machinery or any other potentially dangerous activity until you have determined the effects of trazodone on your mental reaction abilities.
Seizures: A small number of people who have taken trazodone have had seizures. Most of these people were usually receiving medication for an already diagnosed seizure disorder. If you have a history of seizures, discuss with your doctor how Trazodone may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Trazodone, and whether any special monitoring is needed.
Serotonin syndrome: In rare cases, serious life-threatening reactions can occur when trazodone is combined with other drugs that act on serotonin (e.g. tricyclic antidepressants and serotonin reuptake inhibitors, other drugs used to treat depression). This phenomenon is called serotonin syndrome. Such combinations of drugs should be avoided. The symptoms of a reaction are, among other things, muscle rigidity and spasms, difficulty moving, impaired mental state - including delirium and agitation. Coma and death could also occur.
Pregnancy: The safety of trazodone during pregnancy has not been established. Orciprenaline should not be taken by women who may become pregnant, unless their doctor considers that the intended benefits are greater than the possible risks. If you are pregnant or may be pregnant, discuss with your doctor the risks and benefits of allopurinol.
Breastfeeding: trazodone passes into breast milk. If you are breast-feeding your baby while taking Trazodone, it may affect your baby. Contact your doctor to find out if you should continue breastfeeding.
Children and adolescents: Neither the safety nor the effectiveness of trazodone has been established with regard to people under 18 years of age.
Seniors: People over the age of 65 may be at greater risk of experiencing the adverse effects of Trazodone and it may be necessary for her to take lower doses.
Can other medicines interact with Trazodone?
There could be an interaction between tradozone and one of the following medicines :
- antiparkinsonian agents (e.g. bromocriptine, entacapone, pramipexole, rasagiline, safinamide, selegiline)
- alcohol
- amphetamines (e.g. dextroamphetamine, lisdexamfetamine)
- opioid analgesics (e.g. codeine, morphine)
- serotonin antagonists (anti-emetic drugs; e.g. granisetron, ondansetron)
- antiarrhythmic drugs (e.g. amiodarone, disopyramide, flecainide, procainamide, quinidine, sotalol)
- macrolide antibiotics (e.g. clarithromycin, erythromycin)
- anticonvulsants (e.g. clobazam, gabapentin, levetiracetam, phenobarbital, phenytoin, primidone, topiramate, valproic acid, zonisamide)
- tricyclic antidepressants (e.g. amitriptyline, desipramine, trimipramine)
- antifungals whose name ends in "azole" (e.g. itraconazole, ketoconazole, posaconazole, voriconazole)
- antihistamines (e.g. cetirizine, diphenhydramine, doxylamine, hydroxyzine, loratadine, olopatadine, rupatadine)
- antipsychotics (e.g. chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
- apalutamide
- the aprepitant
- azelastine
- benzodiazepines (e.g. alprazolam, diazepam, lorazepam)
- methylene blue
- bosentan
- brimonidine
- buprenorphine
- buspirone
- butorphanol
- cabergoline
- cannabis
- clonidine
- cobicistat
- conivaptan
- deferasirox
- dexmethylphenidate
- dextromethorphan
- diltiazem
- elagolix
- enzalutamide
- esketamine
- flibanserin
- chloral hydrate
- monoamine oxidase inhibitors (MAOIs; e.g. moclobemide, phenelzine, tranylcypromine)
- HIV protease inhibitors (e.g. atazanavir, indinavir, ritonavir, saquinavir)
- protein kinase inhibitors (e.g. dasatinib, imatinib, lapatinib, pazopanib, sunitinib)
- non-nucleoside HIV reverse transcriptase inhibitors (NNRTIs; e.g. efavirenz, etravirine, nevirapine)
- selective serotonin reuptake inhibitors (SSRIs; e.g. citalopram, fluoxetine, paroxetine, sertraline)
- selective serotonin-norepinephrine reuptake inhibitors or SSRIs (e.g. desvenlafaxine, duloxetine, levomilnacipran, venlafaxine)
- grapefruit juice
- lemborexant
- linezolid
- lithium
- lumacaftor and the ivacaftor
- medicines of the "triptan" type against migraine (e.g. sumatriptan, zolmitriptan)
- ergotamine-type drugs (e.g. dihydroergotamine, ergotamine, methylergonovine)
- methadone
- methylphenidate
- metoclopramide
- mifepristone
- mirtazapine
- mitotane
- modafinil
- ozanimod
- pomalidomide
- quinine
- muscle relaxants (e.g. cyclobenzaprine, baclofen, methocarbamol, tizanidine)
- rifabutin
- rifampin
- ropinirole
- rotigotine
- sarilumab
- scopolamine
- siltuximab
- tapentadol
- tetrabenazine
- tocilizumab
- tramadol
- tryptophan
- verapamil
- warfarin
- zolpidem
- zopiclone
If you are taking any of these medicines, consult your doctor or a pharmacist. In your case, your doctor may ask you to :
- stop taking any of the medicines
- replace one of the drugs with another
- change the way you take one or both of the medicines
- do not change anything at all
The interference of one drug with another does not always lead to the interruption of taking one of them. Ask your doctor what is the best course of action in case of drug interactions.
Other medicines than those listed earlier may interact with Trazodone. Tell your doctor about everything you are taking, whether prescription or over-the-counter medications and herbal remedies. Do not forget to mention any supplement that you take. If you consume caffeine, alcohol, nicotine or illegal drugs, you should inform your prescribing doctor because these substances can modify the action of many medications.
